The prospective mathematical idea satisfying both radiation hormesis under low radiation doses and linear non-threshold theory under high radiation doses
نویسندگان
چکیده
منابع مشابه
Radiation hormesis and adoptive response induced by low doses of limiting radiation
Ionizing radiation has long been known to produce detrimental biological effects. Although these harmful effects are the results of high doses of exposure, some other maladies such as mutation and cancer seems to be induced at low doses of exposure. In recent decades, however, some pioneer scientists have indicated that ionizing radiation like many other essential agents has toxic effects ...
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The atomic bomb survivor cancer mortality data have been used in the past to justify the use of the linear no-threshold (LNT) model for estimating the carcinogenic effects of low dose radiation. An analysis of the recently updated atomic bomb survivor cancer mortality dose-response data shows that the data no longer support the LNT model but are consistent with a radiation hormesis model when a...
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The “Linear No Threshold” hypothesis, used in all radiation protection practices, assumes that all doses, no matter how low, increase risk. However, in human and other mammalian cells, low doses of low LET radiation such as gamma and X-rays induce an adaptive response that protects against both radiation-induced and spontaneous risk. An in vivo test of the hypothesis in mice showed that a 100-m...
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Previous research has demonstrated that adding a very small gamma-ray dose to a small alpha radiation dose can completely suppress lung cancer induction by alpha radiation (a gamma-ray hormetic effect). Here we investigated the possibility of gamma-ray hormesis during low-dose neutron irradiation, since a small contribution to the total radiation dose from neutrons involves gamma rays. Using bi...
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Low doses in the mGy range cause a dual effect on cellular DNA. One is a relatively low probability of DNA damage per energy deposition event and increases in proportion to the dose. At background exposures this damage to DNA is orders of magnitude lower than that from endogenous sources, such as reactive oxygen species. The other effect at comparable doses is adaptive protection against DNA da...
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2020
ISSN: 1880-7062
DOI: 10.1186/s41021-020-0145-4